Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8823418 | 1.00 | ARG1 (0.37) | ARG1ARG2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL8791713 | 1.00 | ARG1 (0.37) | ARG1ARG2CHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL7809370 | 0.93 | ARG1 (0.43) | ARG1ARG2CHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL7809367 | 0.93 | ARG1 (0.43) | ARG1ARG2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL23394417 | 0.81 | ARG1 (0.34) | ARG1ARG2SLC1A2 | |
| SCHEMBL30557090 | 0.81 | ARG1 (0.34) | ARG1ARG2SLC1A2 | |
| SCHEMBL14216687 | 0.80 | SLC1A2 (0.54) | ARG1ARG2SLC1A2 | |
| SCHEMBL2033263 | 0.80 | SLC1A2 (0.54) | ARG1ARG2SLC1A2 | |
| SCHEMBL7672628 | 0.80 | SLC1A2 (0.54) | ARG1ARG2SLC1A2 | |
| SCHEMBL2033261 | 0.80 | SLC1A2 (0.54) | ARG1ARG2SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500841-B1 | ADMINISTERING ENZYME/TRANSFERASE INHIBITORS SUCH AS N-(N-(AMINO-3-MERCAPTOPROPYLAMINO)-3-METHYLPENTYL)-1,2,3,4-TETRAHYDRO-3 -ISOQUINOLINECARBOXYL)-METHIONINE METHYL ESTER, AS ANTICARCINOGENIC AGENTS OR PRODRUGS | MERCK & CO., INC. | 2002-12-31 | — | — | US | disclosed |
| EP-0755383-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1997-08-27 | — | — | EP | disclosed |
| EP-0783518-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5627202-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0755383-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995025092-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-09-21 | — | — | WO | disclosed |
| US-5439918-A | Prodrug for cancer therapy | MERCK & CO., INC. (US) | 1995-08-08 | — | — | US | disclosed |