Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804377 | 0.90 | CYP11B1 (0.40) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL13089068 | 0.87 | TDP1 (0.41) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL11891094 | 0.87 | ALDH1A1 (0.41) | ALDH1A1TDP1CYP11B1CYP11B2GRN | |
| SCHEMBL11891101 | 0.85 | KMT2A (0.41) | ALDH1A1TDP1CYP11B1CYP11B2ALOX15 | |
| SCHEMBL8370305 | 0.84 | TDP1 (0.36) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL23704518 | 0.83 | AKT1 (0.40) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL8365795 | 0.83 | ALDH1A1 (0.35) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL3072100 | 0.79 | GAA (0.45) | ALDH1A1TDP1CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8539803 | 0.79 | ALDH1A1 (0.33) | ALDH1A1TDP1CYP11B1CYP11B2MAPK1 | |
| SCHEMBL7460094 | 0.79 | HDAC3 (0.40) | MAPK1HDAC3HDAC6MAPTTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-0675112-A1 | Imidazole-containing inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |