Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537689 | 1.00 | ALDH1A1 (0.33) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL8365821 | 0.91 | LTC4S (0.35) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL8365636 | 0.86 | ALDH1A1 (0.32) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL8368241 | 0.85 | ALDH1A1 (0.31) | ALDH1A1TDP1CYP11B1CYP11B2HDAC3 | |
| SCHEMBL8365784 | 0.85 | ALDH1A1 (0.31) | ALDH1A1TDP1CYP11B1CYP11B2HDAC3 | |
| SCHEMBL9052227 | 0.80 | ALDH1A1 (0.35) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL9052220 | 0.80 | — | — | |
| SCHEMBL27804377 | 0.79 | CYP11B1 (0.40) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL7683395 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 | |
| SCHEMBL7507021 | 0.77 | GPBAR1 (0.33) | ALDH1A1TDP1CYP11B1CYP11B2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837679-A4 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0837679-A1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | Gliatech, Inc. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996038141-A1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH, INC. (US) | 1996-12-05 | — | — | WO | disclosed |