Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687672 | 0.94 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53MAPTCSNK2A2CSNK2B | |
| SCHEMBL7687645 | 0.90 | POLB (0.41) | SMN1; SMN2TP53MAPTCSNK2A2CSNK2B | |
| SCHEMBL7685489 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53MAPTCSNK2A2CSNK2B | |
| SCHEMBL7689473 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2TP53MAPTRECQLALDH1A1 | |
| SCHEMBL7683958 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2TP53MAPTRECQLALDH1A1 | |
| Hydrochloric Acid SCHEMBL7689722 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7683074 | 0.68 | TSHR (0.46) | SMN1; SMN2TP53MAPTRECQLALDH1A1 | |
| Hydrochloric Acid SCHEMBL7680956 | 0.68 | POLB (0.36) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7687676 | 0.68 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53MAPTRECQLALDH1A1 | |
| SCHEMBL7685133 | 0.66 | TP53 (0.47) | SMN1; SMN2TP53MAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |