Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674925 | 0.90 | HPGD (0.52) | POLBGAAALDH1A1MAPK8KMT2A | |
| SCHEMBL7371026 | 0.89 | POLB (0.47) | POLBGAAALDH1A1MAPK8KMT2A | |
| SCHEMBL7364476 | 0.88 | PARP10 (0.48) | POLBGAAALDH1A1MAPK8KMT2A | |
| SCHEMBL7362102 | 0.86 | POLB (0.46) | POLBGAAMAPK8KMT2AHPGD | |
| SCHEMBL7371277 | 0.85 | ALDH1A1 (0.48) | POLBGAAALDH1A1MAPK8 | |
| SCHEMBL7405218 | 0.81 | MAPK8 (0.47) | POLBALDH1A1MAPK8CYP2C19 | |
| SCHEMBL7405222 | 0.81 | MAPK8 (0.47) | POLBALDH1A1MAPK8CYP2C19 | |
| SCHEMBL7368043 | 0.78 | POLB (0.48) | POLBGAAALDH1A1MAPK8 | |
| SCHEMBL3454297 | 0.77 | CYP1A2 (0.62) | POLBGAAALDH1A1KMT2ACYP2C19 | |
| SCHEMBL7679786 | 0.76 | KMT2A (0.50) | GAAMAPK8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |