Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371912 | 0.95 | P2RX7 (0.47) | POLBMAPK8 | |
| SCHEMBL7368886 | 0.81 | MAPK8 (0.50) | POLBMAPK8 | |
| SCHEMBL7371277 | 0.81 | ALDH1A1 (0.48) | POLBMAPK8ALDH1A1GAACACNA1I | |
| SCHEMBL7370304 | 0.80 | HPGD (0.62) | POLBMAPK8GAA | |
| SCHEMBL7374717 | 0.79 | MAPK8 (0.48) | POLBMAPK8GAA | |
| SCHEMBL7370770 | 0.79 | MAPK8 (0.50) | POLBMAPK8ALDH1A1 | |
| SCHEMBL7369860 | 0.79 | MAPK8 (0.50) | POLBMAPK8ALDH1A1 | |
| SCHEMBL7683603 | 0.78 | POLB (0.54) | POLBMAPK8ALDH1A1GAA | |
| SCHEMBL7367990 | 0.78 | RAB9A (0.52) | POLBALDH1A1GAA | |
| SCHEMBL7677336 | 0.78 | ALDH1A1 (0.42) | POLBMAPK8ALDH1A1GAACACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |