SCHEMBL7683629

SCHEMBL7683629

CC(O)=C1C(=O)CC(c2cc(Cl)sc2Cl)CC1=O

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.35
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7678938 0.68
SCHEMBL25308839 0.58 TDP1 (0.39) DAOPKM
SCHEMBL660889 0.57 DAO (0.55) DAOMEN1KMT2A
SCHEMBL542159 0.56 DAO (0.65) DAOHPGDKMT2A
SCHEMBL11758390 0.55 GPR35 (0.36) DAO
SCHEMBL7827700 0.54 DAO (0.46) DAOHPGD
SCHEMBL7827703 0.54 DAO (0.46) DAOHPGD
SCHEMBL792551 0.53 DAO (1.00) DAOHPGDKMT2A
SCHEMBL27531650 0.52 DAO (0.44) DAOHPGD
SCHEMBL14434109 0.52 DAO (0.54) DAOHPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350749-B1 SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-02-26 US disclosed
EP-1057812-A1 AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-12-06 EP disclosed