Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.48 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370360 | 0.87 | UCHL1 (0.47) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL369012 | 0.83 | UCHL1 (0.44) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL369288 | 0.79 | UCHL1 (0.49) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL15595830 | 0.79 | UCHL1 (0.51) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL6837142 | 0.77 | UCHL1 (0.64) | UCHL1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL15182512 | 0.76 | UCHL1 (0.52) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL369251 | 0.75 | UCHL1 (0.53) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL20154072 | 0.75 | UCHL1 (0.45) | UCHL1AADATMEN1NPC1RAB9A | |
| SCHEMBL1051278 | 0.70 | UCHL1 (0.52) | UCHL1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4317065 | 0.69 | MAPT (0.50) | UCHL1MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006760-A1 | TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012008999-A2 | TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |