Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 13/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 12/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550502 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6548685 | 0.83 | PRMT5 (0.50) | KDM4EALDH1A1MAPTPRMT5WDR77 | |
| SCHEMBL6548688 | 0.83 | PRMT5 (0.50) | KDM4EALDH1A1MAPTPRMT5WDR77 | |
| SCHEMBL28748161 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL7673625 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL7677798 | 0.79 | PRMT5 (0.59) | PRMT5WDR77MEN1KMT2A | |
| SCHEMBL7677794 | 0.79 | PRMT5 (0.59) | PRMT5WDR77MEN1KMT2A | |
| SCHEMBL11903909 | 0.79 | TTR (0.65) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL11903912 | 0.79 | TTR (0.65) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL12731827 | 0.79 | TTR (0.65) | KDM4EALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500823-B1 | ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES | N-GENE RESEARCH LABORATORIES, INC. | 2002-12-31 | — | — | US | claimed |