Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6548688 | 1.00 | PRMT5 (0.50) | PRMT5WDR77KMT2AMEN1KDM4E | |
| SCHEMBL6548940 | 0.86 | PRMT5 (0.54) | PRMT5WDR77MAPT | |
| SCHEMBL6548825 | 0.85 | KDM4E (0.60) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL6548832 | 0.85 | KDM4E (0.60) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL7683852 | 0.83 | KDM4E (0.56) | PRMT5WDR77KMT2AMEN1KDM4E | |
| SCHEMBL6550528 | 0.83 | PDE4D (0.60) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6550533 | 0.83 | PDE4D (0.60) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL6550294 | 0.73 | NFE2L2 (0.45) | KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6550288 | 0.73 | NFE2L2 (0.45) | KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6548872 | 0.71 | ABCB1 (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115697-B1 | UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS | GENE KUTATO KFT N (HU) | 2004-02-04 | — | — | EP | disclosed |
| US-6500823-B1 | ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES | N-GENE RESEARCH LABORATORIES, INC. | 2002-12-31 | — | — | US | disclosed |
| EP-1115697-A1 | UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS | N-Gene Kutato KFT. (HU) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000014054-A1 | UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS | N-Gene Kutató Kft. (HU) | 2000-03-16 | — | — | WO | disclosed |