Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.37 |
| ▸ | CASP3 | P42574 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686996 | 0.97 | CASP1 (0.39) | CASP1CASP3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7683785 | 0.89 | DGAT1 (0.33) | CASP3ALDH1A1SMN1; SMN2MAPTCTSA | |
| SCHEMBL7684058 | 0.88 | CASP1 (0.44) | CASP1CASP3TP53 | |
| SCHEMBL7684781 | 0.88 | CASP1 (0.38) | CASP1CASP3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8171648 | 0.87 | CASP1 (0.36) | CASP1ALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL7676798 | 0.87 | CASP1 (0.37) | CASP1CASP3ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7675668 | 0.86 | CASP1 (0.40) | CASP1CASP3 | |
| SCHEMBL7686539 | 0.85 | CTSA (0.34) | CASP3ALDH1A1SMN1; SMN2MAPTCTSA | |
| SCHEMBL7679587 | 0.85 | CASP1 (0.36) | CASP1CASP3CTSA | |
| SCHEMBL7682036 | 0.85 | CASP1 (0.38) | CASP1CASP3SMN1; SMN2CTSARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136834-A | TETRAZOLE PEPTIDES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | claimed |
| EP-0900791-A1 | TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-03-10 | — | — | EP | claimed |
| US-6376484-B1 | FOR PREVENTION AND/OR TREATMENT OF VARIOUS KINDS OF INFLAMMATORY DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-04-23 | — | — | US | disclosed |
| US-6136834-A | TETRAZOLE PEPTIDES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0900791-A1 | TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-03-10 | — | — | EP | disclosed |