Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 13/20 | 0.54 |
| ▸ | HTR1A | P08908 | 12/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 12/20 | 0.54 |
| ▸ | HTR1B | P28222 | 12/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.54 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670362 | 0.86 | HTR1A (0.57) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6994182 | 0.86 | HTR1A (0.73) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7675942 | 0.85 | HTR1A (0.53) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| Hydrochloric Acid SCHEMBL7719556 | 0.85 | HTR1A (0.72) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7677441 | 0.84 | ADRA1B (0.74) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6999823 | 0.84 | HTR1A (0.56) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7676939 | 0.82 | HTR1A (0.53) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7676264 | 0.78 | HTR1A (0.48) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7012836 | 0.78 | KDM4E (0.49) | ADRA1BHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL6991454 | 0.77 | HTR1A (0.73) | ADRA1BHTR1AADRA1DHTR1BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6355647-B1 | INHIBIT THE SEROTONIN REUPTAKE. HYPERPROLACTINEMIA, VASOSPASMS, HYPERTENSION, GASTROINTESTINAL DISORDERS ASSOCIATED WITH MOTILITY AND SECRETION | ABBOTT LABORATORIES | 2002-03-12 | — | — | US | disclosed |