Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677512 | 0.92 | KMT2A (0.53) | KMT2AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7372342 | 0.90 | PDE10A (0.48) | KMT2AALDH1A1 | |
| SCHEMBL7400057 | 0.88 | KMT2A (0.49) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369624 | 0.88 | KMT2A (0.57) | KMT2AALDH1A1 | |
| SCHEMBL7368595 | 0.84 | KMT2A (0.50) | KMT2AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7402170 | 0.82 | KMT2A (0.48) | KMT2AALDH1A1 | |
| SCHEMBL7368614 | 0.79 | KMT2A (0.49) | KMT2AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7399550 | 0.77 | MAPK8 (0.57) | KMT2AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7374580 | 0.76 | KMT2A (0.43) | KMT2AROCK2PDE4APDE4BPDE4C | |
| SCHEMBL5529298 | 0.76 | RAB9A (0.68) | ALDH1A1ROCK2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |