Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684145 | 0.77 | CRHR1 (0.54) | TSHRALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL7677447 | 0.76 | CRHR1 (0.53) | TSHRMAPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7684260 | 0.71 | CRHR1 (0.48) | TSHRALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL7676298 | 0.71 | CRHR1 (0.48) | TSHRALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL7554809 | 0.66 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL7783163 | 0.60 | CRHR1 (0.39) | MAPTALDH1A1TP53KDM4EHPGD | |
| SCHEMBL13643834 | 0.59 | LMNA (0.60) | TSHRMAPTLMNACREBBPALDH1A1 | |
| SCHEMBL12864867 | 0.59 | MAPT (0.64) | TSHRMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL20843105 | 0.57 | BCL2L1 (0.57) | MAPTLMNASMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL22335506 | 0.57 | BCL2L1 (0.41) | MAPTALDH1A1MAPK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |