SCHEMBL7685311

SCHEMBL7685311

[C]1CC=Cc2ccccc2S1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29569587 0.69 MEN1 (0.30)
SCHEMBL44493 0.69 MEN1 (0.30)
SCHEMBL3643757 0.69 MEN1 (0.30)
SCHEMBL677570 0.67
SCHEMBL2514498 0.65 TRPA1 (0.37)
SCHEMBL4862177 0.64
SCHEMBL30640023 0.64 MEN1 (0.31)
SCHEMBL6759882 0.64
SCHEMBL6200557 0.64 MEN1 (0.35)
SCHEMBL7465889 0.62 KDM4E (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498190-B1 TREATMENT OF NASAL OCCLUSION AND MAST CELL DYSFUNCTION DISEASES; ANTIINFLAMMATORY AGENTS SHIONOGI & CO., LTD. (JP) 2002-12-24 US claimed
EP-0837052-A1 BICYCLIC AMINO DERIVATIVES AND PGD 2 ANTAGONIST CONTAINING THE SAME SHIONOGI & CO., LTD. (JP) 1998-04-22 EP claimed
CN-116568668-A Pentaneamidine analogues and methods of treating infections 美商奥润沙公司 2023-08-08 CN disclosed
US-20220040318-A1 PRIMARY AMINE COMPOUND OR SECONDARY AMINE COMPOUND-ACIDIC POLYSACCHARIDE CONJUGATE AND PRODUCTION METHOD THEREFOR SEIKAGAKU CORPORATION (JP) 2022-02-10 US disclosed
US-20200138964-A1 TERTIARY AMINE COMPOUND OR IMINE COMPOUND-POLYMER CONJUGATE AND PRODUCTION METHOD THEREFOR SEIKAGAKU CORPORATION (JP) 2020-05-07 US disclosed
WO-2020067507-A1 PRIMARY AMINE COMPOUND- OR SECONDARY AMINE COMPOUND-ACIDIC POLYSACCHARIDE CONJUGATE, AND METHOD FOR PRODUCING SAME 生化学工業株式会社 2020-04-02 WO disclosed
US-6498190-B1 TREATMENT OF NASAL OCCLUSION AND MAST CELL DYSFUNCTION DISEASES; ANTIINFLAMMATORY AGENTS SHIONOGI & CO., LTD. (JP) 2002-12-24 US disclosed
US-6384075-B1 TREATING DISEASES IN WHICH MAST CELL DYSFUNCTION IS INVOLVED SHIONOGI & CO., LTD. (JP) 2002-05-07 US disclosed
US-6172113-B1 Bicyclic amino derivatives and PGD2 antagonist containing the same SHIONOGI & CO., LTD. (JP) 2001-01-09 US disclosed
EP-0837052-A1 BICYCLIC AMINO DERIVATIVES AND PGD 2 ANTAGONIST CONTAINING THE SAME SHIONOGI & CO., LTD. (JP) 1998-04-22 EP disclosed
US-4560447-A Electrolytic process for preparation of α-alkylated acetic acid derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1985-12-24 US disclosed