Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684068 | 0.93 | MAPT (0.53) | MAPTKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL7682259 | 0.92 | MEN1 (0.54) | MAPTKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL7686202 | 0.84 | ADORA1 (0.61) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL7685507 | 0.84 | MEN1 (0.60) | MAPTKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL7685323 | 0.77 | ALDH1A1 (0.53) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7682075 | 0.77 | MEN1 (0.52) | MAPTKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL20838883 | 0.76 | MAPT (0.56) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL7001600 | 0.76 | ADORA1 (0.67) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL6318321 | 0.74 | ADORA1 (0.68) | MAPTKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL5342374 | 0.74 | MAPT (0.63) | MAPTKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403606-B1 | ANTIINFLAMMATORY, ANTIARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6046189-A | ANTI-INFLAMMATORY DRUG, PARTICULARLY, A DRUG FOR PREVENTING OR TREATING ARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-04-04 | — | — | US | disclosed |