Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682259 | 0.93 | MEN1 (0.54) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL7682075 | 0.92 | MEN1 (0.52) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL7684068 | 0.91 | MAPT (0.53) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL7685324 | 0.84 | MAPT (0.49) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL7001600 | 0.78 | ADORA1 (0.67) | MEN1KMT2AKDM4EMAPTADORA1 | |
| SCHEMBL135885 | 0.76 | MEN1 (0.65) | MEN1KMT2AKDM4EMAPTMAPK1 | |
| SCHEMBL9142756 | 0.74 | MEN1 (0.56) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL20838883 | 0.73 | MAPT (0.56) | MEN1KMT2AKDM4EMAPTRECQL | |
| SCHEMBL7685323 | 0.72 | ALDH1A1 (0.53) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5712947 | 0.72 | MEN1 (0.62) | MEN1KMT2AKDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403606-B1 | ANTIINFLAMMATORY, ANTIARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6046189-A | ANTI-INFLAMMATORY DRUG, PARTICULARLY, A DRUG FOR PREVENTING OR TREATING ARTHRITIS, A DRUG FOR INHIBITING BONE RESORPTION, IMMUNOSUPPRESSANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0900223-A1 | THIENOPYRIDINE DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997040050-A1 | THIENOPYRIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |