Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 9/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685430 | 1.00 | LSS (0.57) | LSSACHEOPRM1OPRK1KCNH2 | |
| SCHEMBL7685855 | 0.87 | LSS (0.57) | LSSACHEVNN1DPP4DPP9 | |
| SCHEMBL7685852 | 0.87 | LSS (0.57) | LSSACHEVNN1DPP4DPP9 | |
| SCHEMBL7768086 | 0.78 | VNN1 (0.40) | ACHEOPRM1OPRK1KCNH2VNN1 | |
| SCHEMBL7685431 | 0.78 | VNN1 (0.40) | ACHEOPRM1OPRK1KCNH2VNN1 | |
| SCHEMBL23752312 | 0.73 | LSS (1.00) | LSS | |
| SCHEMBL7679278 | 0.73 | LSS (1.00) | LSS | |
| SCHEMBL3700933 | 0.72 | LSS (0.71) | LSS | |
| SCHEMBL7684578 | 0.72 | LSS (0.71) | LSS | |
| SCHEMBL3676963 | 0.69 | LSS (0.52) | LSSACHETHRATHRBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | claimed |
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |