Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 17/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766682 | 0.89 | TRPV1 (0.71) | TRPV1KCNH2 | |
| SCHEMBL766902 | 0.81 | TRPV1 (0.69) | TRPV1KCNH2 | |
| SCHEMBL766493 | 0.77 | TRPV1 (0.84) | TRPV1KCNH2 | |
| SCHEMBL766386 | 0.76 | TRPV1 (0.78) | TRPV1 | |
| SCHEMBL766863 | 0.75 | TRPV1 (0.84) | TRPV1KCNH2 | |
| SCHEMBL766697 | 0.75 | TRPV1 (0.73) | TRPV1KCNH2 | |
| SCHEMBL11931673 | 0.75 | TRPV1 (0.77) | TRPV1NPC1RAB9AMEN1S1PR1 | |
| SCHEMBL11931676 | 0.75 | TRPV1 (0.82) | TRPV1NPC1RAB9AMEN1S1PR1 | |
| SCHEMBL766757 | 0.75 | TRPV1 (0.71) | TRPV1KCNH2 | |
| SCHEMBL766283 | 0.75 | TRPV1 (0.72) | TRPV1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885NPC1 1369/4885RAB9A 2050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.