Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9619202 | 1.00 | — | — | |
| Bicarbonate SCHEMBL8018961 | 1.00 | LMNA (0.41) | LMNATSHRALDH1A1TP53CA1 | |
| Acetic Acid SCHEMBL28925246 | 0.90 | — | — | |
| Bicarbonate SCHEMBL14053443 | 0.83 | LMNA (0.39) | LMNATSHRALDH1A1TP53CA1 | |
| Urea SCHEMBL9579184 | 0.83 | — | — | |
| Bicarbonate SCHEMBL9202821 | 0.83 | — | — | |
| SCHEMBL10794029 | 0.80 | — | — | |
| SCHEMBL20151 | 0.80 | — | — | |
| Bicarbonate SCHEMBL28731859 | 0.80 | — | — | |
| Bicarbonate SCHEMBL17581395 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764628-B1 | Diesters of pyrocarbonic acid, their preparation and their use | CIBA SC HOLDING AG (CH) | 2001-03-14 | — | — | EP | claimed |
| US-5750758-A | DEHYDRATION OF CARBONIC ACID | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-05-12 | — | — | US | claimed |
| EP-3233868-B1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | BASF SE (DE) | 2018-09-18 | — | — | US | disclosed |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | BASF SE (DE) | 2017-12-21 | — | — | US | disclosed |
| US-6359122-B1 | Pyrocarbonic acid diesters and the preparation and use thereof | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-03-19 | — | — | US | disclosed |
| US-6222047-B1 | PIGMENT PRECURSORS | CIBA SPECIALTY CHEMICALS CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-6063924-A | N-(ALKENYL OR ALKYNYL)OXYCARBONYL SUBSTITUTED CHROMOPHORE DERIVATIVES; SOLUBLE ORGANIC PIGMENTS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-05-16 | — | — | US | disclosed |
| US-5750758-A | DEHYDRATION OF CARBONIC ACID | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | OR10J3, OR51E2, OXER1 | LMNA 3332/4885TSHR 2680/4885ALDH1A1 1250/4885 |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | OR10J3, NR0B1, NR0B2 | LMNA 2964/4885TSHR 2401/4885ALDH1A1 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.