Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.43 |
| ▸ | FNTB | P49356 | 11/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.43 |
| ▸ | HRAS | P01112 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685758 | 1.00 | FNTA (0.43) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL18041271 | 0.75 | FNTA (0.61) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL21877258 | 0.75 | FNTA (0.61) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL18041272 | 0.75 | FNTA (0.61) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL5755053 | 0.72 | FNTA (0.62) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL5790292 | 0.72 | FNTA (0.62) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL6614317 | 0.69 | FNTA (0.58) | FNTAFNTBPGGT1BHRASKRAS | |
| SCHEMBL7693749 | 0.68 | FNTA (0.38) | FNTAFNTBKMT2A | |
| SCHEMBL7693752 | 0.68 | FNTA (0.38) | FNTAFNTBKMT2A | |
| SCHEMBL7693756 | 0.68 | FNTA (0.38) | FNTAFNTBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458783-B1 | INHIBITION OF FARNESYL TRANSFERASE, WHICH IS AN ENZYME INVOLVED IN RAS ONCOGENE EXPRESSION, IS EFFECTED BY COMPOUNDS OF THE FORMULAS OF BENODIAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |