Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.38 |
| ▸ | FNTB | P49356 | 6/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7693749 | 1.00 | FNTA (0.38) | FNTAFNTBMMP2BACE1KMT2A | |
| SCHEMBL7693756 | 1.00 | FNTA (0.38) | FNTAFNTBMMP2BACE1KMT2A | |
| SCHEMBL7691593 | 0.69 | POLB (0.37) | FNTAFNTBKMT2A | |
| SCHEMBL7685758 | 0.68 | FNTA (0.43) | FNTAFNTBKMT2A | |
| SCHEMBL7685754 | 0.68 | FNTA (0.43) | FNTAFNTBKMT2A | |
| SCHEMBL6614995 | 0.67 | FNTA (0.56) | FNTAFNTBMMP2 | |
| SCHEMBL6633343 | 0.67 | FNTA (0.56) | FNTAFNTBMMP2 | |
| SCHEMBL7238870 | 0.65 | SLC6A2 (0.41) | FNTAFNTB | |
| SCHEMBL9448311 | 0.65 | STS (0.39) | FNTAFNTB | |
| SCHEMBL9448316 | 0.65 | STS (0.39) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458783-B1 | INHIBITION OF FARNESYL TRANSFERASE, WHICH IS AN ENZYME INVOLVED IN RAS ONCOGENE EXPRESSION, IS EFFECTED BY COMPOUNDS OF THE FORMULAS OF BENODIAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-2001081322-A1 | NON-IMIDAZOLE BENZODIAZEPINE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |