Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 5/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | KYNU | Q16719 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRND | Q07001 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679450 | 0.87 | TRPV1 (0.48) | ANPEPERAP2ERAP1SLC1A3SLC1A2 | |
| SCHEMBL4061971 | 0.86 | FOLH1 (0.50) | ANPEPFOLH1 | |
| SCHEMBL7591136 | 0.83 | KMT2A (0.42) | FOLH1SLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL4063820 | 0.82 | KDM4E (0.37) | HPGDSHIF1ACYP1A2 | |
| SCHEMBL7681396 | 0.81 | AKR1B1 (0.37) | ERAP2ERAP1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4061937 | 0.79 | HMGB1 (0.34) | SLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL4063724 | 0.79 | BID (0.36) | ERAP2ERAP1HPGDSFOLH1SLC1A3 | |
| SCHEMBL4063727 | 0.79 | ANPEP (0.49) | GRIA2ANPEPERAP2ERAP1HPGDS | |
| SCHEMBL4070496 | 0.78 | HMGB1 (0.39) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4071551 | 0.78 | PPARG (0.39) | SLC1A3SLC1A2SLC1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |