Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | IL1RN | P18510 | 2/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063724 | 0.89 | BID (0.36) | AKR1B1EPHX1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4062969 | 0.86 | ADRA1D (0.36) | EPHX1SLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL4070562 | 0.86 | PLA2G10 (0.39) | SLC7A5 | |
| SCHEMBL4061937 | 0.84 | HMGB1 (0.34) | EPHX1SLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL7679450 | 0.83 | TRPV1 (0.48) | EPHX1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4070172 | 0.81 | KMT2A (0.33) | EPHX1SLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL4064377 | 0.81 | ADRA1D (0.35) | EPHX1POLBALDH1A1L3MBTL1 | |
| SCHEMBL4064865 | 0.81 | TDP1 (0.38) | EPHX1SLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL4063820 | 0.81 | KDM4E (0.37) | ALDH1A1CYP1A2TRPV1 | |
| SCHEMBL7685992 | 0.81 | GRIA2 (0.41) | SLC1A3SLC1A2SLC1A1CYP1A2ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |