Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.32 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.32 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.32 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.32 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.32 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063820 | 0.81 | KDM4E (0.37) | PLA2G10PLA2G2AACEPLA2G1BPLA2G5 | |
| SCHEMBL4061937 | 0.79 | HMGB1 (0.34) | HMGB1PLA2G10PLA2G2ACCR1PLA2G1B | |
| SCHEMBL7685992 | 0.78 | GRIA2 (0.41) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4062969 | 0.78 | ADRA1D (0.36) | PLA2G10PLA2G2ACCR1TRPA1L3MBTL1 | |
| SCHEMBL4066977 | 0.78 | CYP3A4 (0.36) | PLA2G10PLA2G2APLA2G1BPLA2G5PLA2G2C | |
| SCHEMBL7679450 | 0.78 | TRPV1 (0.48) | CCR1ACEPOLBSLC1A3SLC1A2 | |
| SCHEMBL4061971 | 0.78 | FOLH1 (0.50) | PLA2G10PLA2G2AOPRM1OPRD1 | |
| SCHEMBL7681396 | 0.75 | AKR1B1 (0.37) | CCR1TRPA1L3MBTL1ALDH1A1POLB | |
| SCHEMBL4070172 | 0.74 | KMT2A (0.33) | PLA2G10PLA2G2ACCR1PLA2G1BPLA2G5 | |
| SCHEMBL4064377 | 0.74 | ADRA1D (0.35) | PLA2G10PLA2G2APLA2G1BPLA2G5PLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |
| EP-0966443-A1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER INC. (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998038167-A1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER INC. (US) | 1998-09-03 | — | — | WO | disclosed |