SCHEMBL7686000

SCHEMBL7686000

C#Cc1cccc2c1C(=O)N(c1ccccc1)C2=O.c1cc2ccc1-2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA1A P0DMV8 1/20 0.56
PABPC1 P11940 1/20 0.56
PDE6D O43924 1/20 0.43
PGR P06401 1/20 0.43
ALDH1A1 P00352 3/20 0.43
POLB P06746 2/20 0.43
ADORA2A P29274 1/20 0.42
KMT2A Q03164 4/20 0.42
USP2 O75604 3/20 0.42
MEN1 O00255 3/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
LMNA P02545 1/20 0.42
TNNI3 P19429 1/20 0.42
TNNT2 P45379 1/20 0.42
TNNC1 P63316 1/20 0.42
KDM4E B2RXH2 2/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19411342 0.87 CA12 (0.57) HSPA1APABPC1POLBKMT2AMEN1
SCHEMBL3447118 0.86 HSPA1A (0.41) HSPA1APABPC1PGRALDH1A1ADORA2A
SCHEMBL28505833 0.85 NPC1 (0.54) HSPA1APABPC1ALDH1A1POLBKMT2A
SCHEMBL6910591 0.85 MEN1 (0.49) HSPA1APABPC1ALDH1A1ADORA2AKMT2A
SCHEMBL28484463 0.85 TYMS (0.62) ALDH1A1POLBKMT2AMEN1MAPT
SCHEMBL10747857 0.81 ADORA2A (0.37) HSPA1APABPC1PDE6DADORA2AKMT2A
SCHEMBL19411348 0.80 KMT2A (0.48) ALDH1A1ADORA2AKMT2AMEN1MAPT
SCHEMBL8627783 0.75 MEN1 (0.45) HSPA1APABPC1PGRPOLBKMT2A
SCHEMBL1500541 0.74 HSPA1A (0.67) HSPA1APABPC1PGRALDH1A1POLB
SCHEMBL7675911 0.74 HSPA1A (0.54) HSPA1APABPC1PDE6DPGRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6395907-B1 Preparation of polyaromatic-ethynyl thermal setting agents VIRGINIA COMMONWEALTH UNIVERSITY 2002-05-28 US disclosed