Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17054190 | 0.92 | L3MBTL1 (0.46) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL17054276 | 0.92 | L3MBTL1 (0.46) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL7688670 | 0.86 | L3MBTL1 (0.54) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL14032279 | 0.84 | L3MBTL1 (0.55) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| Hydrochloric Acid SCHEMBL5967080 | 0.83 | L3MBTL1 (0.54) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL8455849 | 0.80 | L3MBTL1 (0.54) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL28111441 | 0.80 | KMT2A (0.60) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17065349 | 0.80 | KMT2A (0.60) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11081245 | 0.79 | L3MBTL1 (0.56) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 | |
| SCHEMBL2871628 | 0.79 | L3MBTL1 (0.56) | L3MBTL1AOC3MTNR1AMTNR1BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440975-B1 | Amino acid derivatives, the preparation and use thereof as endothelin antagonists | ABBOTT LABORATORIES | 2002-08-27 | — | — | US | disclosed |