Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686083 | 0.86 | L3MBTL1 (0.52) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL9320777 | 0.86 | ACHE (0.61) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL6121064 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL29913554 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL8752178 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL31592687 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL31505889 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL9457197 | 0.83 | L3MBTL1 (0.56) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 | |
| SCHEMBL5289082 | 0.82 | ACP3 (0.54) | L3MBTL1CES2CES1 | |
| Hydrochloric Acid SCHEMBL28851336 | 0.82 | L3MBTL1 (0.55) | L3MBTL1MTNR1AMTNR1BAOC3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440975-B1 | Amino acid derivatives, the preparation and use thereof as endothelin antagonists | ABBOTT LABORATORIES | 2002-08-27 | — | — | US | disclosed |
| EP-0874829-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997012878-A1 | AMINO ACID DERIVATIVES, THE PREPARATION AND USE THEREOF AS ENDOTHELIN ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1997-04-10 | — | — | WO | disclosed |