Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117787 | 0.74 | TSHR (0.48) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL8693299 | 0.72 | AKT1 (0.46) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL7886735 | 0.72 | AKT1 (0.41) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL4064472 | 0.72 | TSHR (0.43) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL3297834 | 0.72 | AKT1 (0.44) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL277919 | 0.72 | AKT1 (0.44) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL5080711 | 0.72 | AKT1 (0.44) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL18585106 | 0.72 | AKT1 (0.44) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL8408014 | 0.71 | CES1 (0.48) | TSHRALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL11108347 | 0.71 | AKT1 (0.40) | TSHRALDH1A1HPGDLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227805-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | Curis, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001026644-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2001-04-19 | — | — | WO | disclosed |