Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 9/20 | 0.51 |
| ▸ | HTR3A | P46098 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651040 | 0.86 | GAA (0.57) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL768661 | 0.85 | HTR4 (0.54) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL15651087 | 0.85 | HTR4 (0.56) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL17471503 | 0.82 | HTR4 (0.67) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL15006201 | 0.81 | HTR4 (0.47) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL7454538 | 0.80 | GAA (0.67) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL15650544 | 0.79 | GAA (0.55) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL7356591 | 0.77 | GAA (0.63) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL14995303 | 0.77 | HTR4 (0.48) | GAAHTR4HTR3ACYP2D6CYP3A4 | |
| SCHEMBL5925563 | 0.76 | GAA (0.61) | GAAHTR4HTR3ACYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | GAA 3182/4885HTR4 571/4885HTR3A 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.