Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523846 | 0.98 | THRB (0.36) | THRBFNTAFNTBPGGT1BGRIK1 | |
| Hydrochloric Acid SCHEMBL9636093 | 0.96 | THRB (0.35) | THRBFNTAFNTBPGGT1BGRIK1 | |
| Chloromethane SCHEMBL6137819 | 0.94 | THRB (0.34) | THRBFNTAFNTBPGGT1BGRIK1 | |
| Diethyl Sulfide SCHEMBL28279890 | 0.88 | TSHR (0.34) | THRBFNTAFNTBPGGT1BGRIK1 | |
| SCHEMBL4746775 | 0.85 | THRB (0.44) | THRBFNTAFNTBPGGT1BGRIK1 | |
| Sulfuric Acid Diethyl Ester SCHEMBL28165117 | 0.84 | CA1 (0.32) | GRIK1CYP1A2 | |
| SCHEMBL1155838 | 0.82 | PAOX (0.52) | THRBFNTAFNTBPGGT1BPAOX | |
| SCHEMBL8930241 | 0.81 | FNTA (0.45) | THRBFNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL27500118 | 0.81 | ALDH1A1 (0.47) | THRBALDH1A1TSHR | |
| SCHEMBL1518639 | 0.80 | PAOX (0.38) | THRBPAOXALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6497283-B1 | CEMENTING USING SLURRY OF WATER, HYDRAULIC CEMENT AND FLUID LOSS CONTROL TERPOLYMER COMPRISING A VINYLSULFONIC ACID, 2-ALLYLOXY-2-HYDROXY-1-PROPANESULFONIC ACID OR 2-ACRYLAMIDO-2-METHYLPROPANESULFONIC ACID MONOMER | HALLIBURTON ENERGY SERVICES, INC. | 2002-12-24 | — | — | US | disclosed |