Histidine

Histidine

SCHEMBL7686781

C[C@@H](OC(=O)[C@@H](N)Cc1ccccc1)[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.46

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 5/20 0.46
ALPI P09923 1/20 0.46
PKM P14618 1/20 0.46
PTGS1 P23219 1/20 0.46
XIAP P98170 1/20 0.46
SLC1A3 P43003 2/20 0.38
SLC1A2 P43004 2/20 0.38
SLC1A1 P43005 2/20 0.38
LTA4H P09960 2/20 0.37
GRIA2 P42262 1/20 0.36
MEN1 O00255 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
PLA2G2A P14555 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP1A2 P05177 1/20 0.35
NOS3 P29474 1/20 0.35
NOS1 P29475 1/20 0.35
NOS2 P35228 1/20 0.35
SLC15A1 P46059 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14809829 0.90 CASR (0.36) SLC7A5CYP1A2
Alanine SCHEMBL6724963 0.88 CASR (0.34) SLC7A5
Threonine SCHEMBL668806 0.87 CASR (0.34)
Phenylalanine SCHEMBL7686784 0.87 SLC7A5 (0.52) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine SCHEMBL8904329 0.85 SLC7A5 (0.56) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine SCHEMBL638657 0.85 SLC7A5 (0.63) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL1007041 0.85 SLC7A5 (0.63) SLC7A5ALPIPKMPTGS1XIAP
Threonine SCHEMBL9114670 0.85 ALPI (0.42) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL22559546 0.85 SLC7A5 (0.50) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL28221311 0.84 SLC7A5 (0.49) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6339150-B1 A GENETICALLY MUTATED VIRICIDE GENE; THERAPY FOR LYMPHADENOPATHY ASSOCIATED VIRUS DUKE UNIVERSITY 2002-01-15 US disclosed
EP-0406557-B1 Multivalent repressor of gene function NOVARTIS AG (CH) 2001-10-17 EP disclosed
US-6287809-B1 PROTEIN WHICH REPRESSES PHENOTYPIC EXPRESSION OF WILD-TYPE REX GENE OF HUMAN T-CELL LEUKEMIA/LYMPHOMA VIRUS-1 OR -2 AND/OR WILD-TYPE REV GENE OF HUMAN IMMUNODEFICIENCY VIRUS-1; VIRICIDES; PROPHYLAXIS NOVARTIS AG (CH) 2001-09-11 US disclosed
US-6251675-B1 MODIFYING CELL BY DELIVERING MUTANT REV GENE HAVING MUTATION FROM AMINO ACID POSITION 68 TO 90 OF THE WILD-TYPE PROTEIN; INTRACELLULAR IMMUNIZATION DUKE UNIVERSITY 2001-06-26 US disclosed
US-6162898-A Mutant Rev transdominant repressors of HIV replication DUKE UNIVERSITY (US) 2000-12-19 US disclosed
US-5871958-A VIRICIDES; GENETIC ENGINEERING DUKE UNIVERSITY (US) 1999-02-16 US disclosed
EP-0406557-A2 Multivalent repressor of gene function SANDOZ LTD. (CH) 1991-01-09 EP disclosed
WO-1990014427-A2 MULTIVALENT REPRESSOR OF GENE FUNCTION SANDOZ LTD (CH) 1990-11-29 WO disclosed