Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL1007041 | 0.95 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL638657 | 0.95 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL22559546 | 0.94 | SLC7A5 (0.50) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL8904139 | 0.94 | SLC7A5 (0.55) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7686784 | 0.91 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL14631617 | 0.91 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28504393 | 0.91 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Histidine SCHEMBL3457996 | 0.91 | SLC7A5 (0.43) | SLC7A5ALPIPKMPTGS1XIAP | |
| Histidine SCHEMBL3335322 | 0.91 | SLC7A5 (0.43) | SLC7A5ALPIPKMPTGS1XIAP | |
| Histidine SCHEMBL4610837 | 0.91 | SLC7A5 (0.43) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652136-A | ENZYME MUTANT WHERE CATALYTIC FUNCTIONALITY HAS BEEN MODIFIED OR REPLACED, MUTANT WILL HAVE PREFERENCE FOR SUBSTRATES SUPPLYING THE MODIFIED OR REPLACED CATALYTIC FUNCTIONAL GROUP | GENENCOR INTERNATIONAL, INC. (US) | 1997-07-29 | — | — | US | claimed |
| US-5472855-A | Genetic engineering forming an enzyme mutants | GENENTECH, INC. (US) | 1995-12-05 | — | — | US | claimed |
| US-5371190-A | Enzyme assisted catalysis | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | claimed |
| US-5371008-A | Catalytically active enzyme-substrate complex comprising a subtilisin-related protease variant in contact with first substrate containing a first selected region | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | claimed |
| US-5652136-A | ENZYME MUTANT WHERE CATALYTIC FUNCTIONALITY HAS BEEN MODIFIED OR REPLACED, MUTANT WILL HAVE PREFERENCE FOR SUBSTRATES SUPPLYING THE MODIFIED OR REPLACED CATALYTIC FUNCTIONAL GROUP | GENENCOR INTERNATIONAL, INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5472855-A | Genetic engineering forming an enzyme mutants | GENENTECH, INC. (US) | 1995-12-05 | — | — | US | disclosed |
| US-5371008-A | Catalytically active enzyme-substrate complex comprising a subtilisin-related protease variant in contact with first substrate containing a first selected region | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5371190-A | Enzyme assisted catalysis | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | disclosed |