Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432352 | 0.77 | GAA (0.82) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL7692074 | 0.76 | GAA (0.55) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5426774 | 0.74 | GAA (0.81) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5426838 | 0.74 | MEN1 (0.87) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5438073 | 0.74 | GAA (0.77) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5430094 | 0.74 | GAA (0.72) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5426953 | 0.72 | GAA (0.77) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL7694205 | 0.72 | ALDH1A1 (0.57) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL5434608 | 0.71 | GAA (0.67) | GAAMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL993820 | 0.70 | CETP (0.74) | GAAMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066447-A1 | 4H-1,2,4-TRIAZOLE-3(2H)-THIONE DERATIVES AS SPHINGOMYELINASE INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |