Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684537 | 0.88 | CRHR1 (0.79) | CRHR1KMT2A | |
| SCHEMBL9045095 | 0.88 | CRHR1 (0.59) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL7678178 | 0.86 | CRHR1 (0.57) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL8047863 | 0.84 | CRHR1 (0.65) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL8047865 | 0.84 | CRHR1 (0.55) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL7685499 | 0.81 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL9048414 | 0.78 | CRHR1 (0.48) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL9046910 | 0.77 | CRHR1 (0.72) | CRHR1KMT2ACRHBPCRHR2NPSR1 | |
| SCHEMBL7684973 | 0.77 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL7682642 | 0.76 | CRHR1 (0.62) | CRHR1KMT2ACRHBPCRHR2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |