Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 10/20 | 0.46 |
| ▸ | DRD1 | P21728 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237279 | 0.94 | DRD3 (0.49) | DRD3DRD1DRD2DRD4SIGMAR1 | |
| SCHEMBL7229472 | 0.93 | DRD3 (0.50) | DRD3DRD1DRD2DRD4HTR1A | |
| SCHEMBL7228845 | 0.91 | DRD2 (0.47) | DRD3DRD1DRD2DRD4SIGMAR1 | |
| SCHEMBL7238427 | 0.88 | DRD3 (0.43) | DRD3DRD1DRD2DRD4HTR1A | |
| SCHEMBL7230735 | 0.85 | DRD2 (0.53) | DRD3DRD1DRD2DRD4HTR1A | |
| SCHEMBL7238666 | 0.85 | HTR1A (0.47) | DRD3DRD1DRD2DRD4HTR1A | |
| SCHEMBL7228815 | 0.85 | GRM5 (0.46) | DRD3DRD1DRD2DRD4HTR1A | |
| SCHEMBL7228916 | 0.85 | DRD3 (0.48) | DRD3DRD1DRD2DRD4SIGMAR1 | |
| SCHEMBL7236689 | 0.85 | DRD3 (0.43) | DRD3DRD1DRD2DRD4SIGMAR1 | |
| SCHEMBL7231842 | 0.85 | DRD3 (0.44) | DRD3DRD1DRD2DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417362-B1 | PIPERAZINE DERIVATIVES; ARTERIOSCLEROSIS, PANCREATITIS, AND CARDIOVASCULAR DISORDER TREATMENT; SIDE EFFECT REDUCTION | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-09 | — | — | US | disclosed |