SCHEMBL7688335

SCHEMBL7688335

CN(C)C(=O)c1ccc(NC=O)cc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 1/20 0.57
LMNA P02545 5/20 0.38
ALDH1A1 P00352 4/20 0.35
MAPT P10636 4/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HPGD P15428 2/20 0.33
CYP2C9 P11712 3/20 0.33
CYP3A4 P08684 2/20 0.33
MAPK1 P28482 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
CYP2D6 P10635 2/20 0.32
CYP2C19 P33261 2/20 0.32
CYP1A2 P05177 1/20 0.32
HTT P42858 1/20 0.32
GSTO1 P78417 1/20 0.32
CCNE2 O96020 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8661476 0.83 CDK1 (0.45) CDK1ALDH1A1MAPTSMN1; SMN2HPGD
SCHEMBL28654796 0.83 CDK1 (0.54) CDK1LMNAALDH1A1SMN1; SMN2NPC1
SCHEMBL7628690 0.83 CDK1 (0.54) CDK1LMNAALDH1A1MAPTHTT
SCHEMBL7686634 0.81 CDK1 (0.46) CDK1LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL7679850 0.81 ATM (0.43) CDK1LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL7683864 0.79 NSD2 (0.39) CDK1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL7924891 0.76 ALDH1A1 (0.36) CDK1LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL8804447 0.75 MEN1 (0.44) LMNAMAPTSMN1; SMN2HPGDKDM4E
SCHEMBL7685851 0.74 L3MBTL1 (0.53) ALDH1A1MAPTHPGDCYP3A4KDM4E
Foramsulfuron SCHEMBL29419146 0.73 CDK1 (1.00) CDK1MAPTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498253-B1 Acylated aminophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators HOECHST SCHERING AGREVO GMBH (DE) 2002-12-24 US disclosed
US-5922646-A PRE-EMERGENCE AND POST-EMERGENCE HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1999-07-13 US disclosed
EP-0757679-B1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-10-21 EP disclosed
EP-0757679-A1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1997-02-12 EP disclosed
WO-1995029899-A1 ACYLATED AMINOPHENYLSULPHONYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1995-11-09 WO disclosed