Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 7/20 | 0.63 |
| ▸ | HTR1A | P08908 | 6/20 | 0.63 |
| ▸ | HTR2A | P28223 | 6/20 | 0.63 |
| ▸ | HTR6 | P50406 | 6/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | HTR7 | P34969 | 6/20 | 0.62 |
| ▸ | HEXA | P06865 | 2/20 | 0.59 |
| ▸ | HEXB | P07686 | 2/20 | 0.59 |
| ▸ | RAD52 | P43351 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12413492 | 0.93 | KDM4E (0.66) | KDM4ELMNAMAPK1DRD2HTR1A | |
| SCHEMBL2363008 | 0.90 | HEXA (0.71) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL14560557 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL20893694 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL9625295 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL9627022 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL9625427 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL1657181 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL9625491 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB | |
| SCHEMBL11455625 | 0.89 | HEXA (0.69) | KDM4EHEXAHEXBRAD52POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420366-B1 | PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. | RANBAXY LABORATORIES LIMITED (IN) | 2002-07-16 | — | — | US | disclosed |
| US-6410735-B1 | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS; BENGIN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2002-06-25 | — | — | US | disclosed |
| US-6090809-A | 1-(4-arylpiperazin-1-yl)-ω-[n-(α..omega.-dicarboximido)]-alkanes useful as uro-selective α1 -adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2000-07-18 | — | — | US | disclosed |
| US-6083950-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY | RANBAXY LABORATORIES LIMITED (IN) | 2000-07-04 | — | — | US | disclosed |