Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 9/20 | 0.34 |
| ▸ | RXRA | P19793 | 7/20 | 0.34 |
| ▸ | RARB | P10826 | 7/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 7/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297298 | 0.83 | RXRA (0.46) | RARARXRARARBRXRGRXRB | |
| SCHEMBL6596539 | 0.82 | RARA (0.44) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL6455060 | 0.80 | KDM4C (0.33) | RARARXRARARBRXRGKDM4C | |
| SCHEMBL8560366 | 0.78 | KDM4C (0.39) | RARARXRARARBRXRGKDM4C | |
| SCHEMBL6292634 | 0.78 | RXRA (0.45) | RARARXRARARBRXRGRXRB | |
| SCHEMBL6708918 | 0.77 | RARA (0.57) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL7162481 | 0.74 | RXRA (0.43) | RARARXRARARBRXRGRXRB | |
| SCHEMBL6294100 | 0.74 | RXRA (0.47) | RARARXRARARBRXRGRXRB | |
| SCHEMBL8558259 | 0.73 | F2 (0.38) | RXRARARBRXRGKDM4CRXRB | |
| SCHEMBL8560364 | 0.73 | CYP3A4 (0.38) | RARARXRARARBRXRGKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465663-B2 | ETHYL (E)-4-(2-(5,6-DIHYDRO-5,5-DIMETHYL-NAPHTHALEN-8(7H)-ONE-2 -YL)ETHENYL)BENZOATE AND ETHYL (E)-4-(2-(5,6-DIHYDRO-5,5-DIMETHYL-8-(PHENYLTHIO)-NAPHTHALENYL)ETHENYL) BENZOATE | ALLERGAN, INC. | 2002-10-15 | — | — | US | disclosed |