Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | PLTP | P55058 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688378 | 0.95 | MEN1 (0.38) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7679779 | 0.93 | TRPV4 (0.37) | MEN1CCKARKMT2ACCR2TRPV4 | |
| SCHEMBL7688220 | 0.92 | TRPV4 (0.35) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7688740 | 0.92 | MEN1 (0.46) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7681850 | 0.91 | TRPV4 (0.35) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7686931 | 0.91 | TRPV4 (0.35) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7683689 | 0.91 | TRPV4 (0.35) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7679733 | 0.90 | TRPV4 (0.36) | MEN1CCKARKMT2ATRPV4TP53 | |
| SCHEMBL7683987 | 0.90 | CCR2 (0.38) | MEN1CCKARKMT2ACCR2TRPV4 | |
| SCHEMBL7681859 | 0.89 | TRPV4 (0.35) | TRPV4TP53MAPTPLTPROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380230-B1 | FOR THERAPY OF DYSKINESIA, OBESITY, IRRITABLE BOWEL SYNDROME, DISEASES WHOSE TREATMENT REQUIRES STIMULATION OF THE CHOLECYSTOKININ CCK-A RECEPTORS | SANOFI-SYNTHELABO (FR) | 2002-04-30 | — | — | US | claimed |
| US-6380230-B1 | FOR THERAPY OF DYSKINESIA, OBESITY, IRRITABLE BOWEL SYNDROME, DISEASES WHOSE TREATMENT REQUIRES STIMULATION OF THE CHOLECYSTOKININ CCK-A RECEPTORS | SANOFI-SYNTHELABO (FR) | 2002-04-30 | — | — | US | disclosed |