Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695066 | 0.87 | MERTK (0.51) | MAPTPOLBALDH1A1GAAHTT | |
| SCHEMBL7695125 | 0.82 | KDM4E (0.51) | GAALMNAMERTKKDM4E | |
| SCHEMBL7695534 | 0.79 | ACP1 (0.45) | ALDH1A1GAAMERTK | |
| SCHEMBL2948725 | 0.76 | MAPT (0.59) | MAPTPOLBPKMALDH1A1GAA | |
| SCHEMBL2376571 | 0.73 | MAPT (0.68) | MAPTPOLBPKMALDH1A1GAA | |
| SCHEMBL7694476 | 0.73 | ALDH1A1 (0.45) | ALDH1A1GAAMAPK1KDM4E | |
| SCHEMBL7690773 | 0.71 | HSD17B10 (0.43) | ALDH1A1GAAMAPK1MERTKKDM4E | |
| SCHEMBL4074395 | 0.71 | FGFR1 (0.52) | MAPTPOLBGAAHTTLMNA | |
| SCHEMBL3185546 | 0.71 | MAPT (0.61) | MAPTPOLBPKMALDH1A1KDM4E | |
| SCHEMBL7694208 | 0.71 | TNKS (0.41) | MAPTPOLBALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076954-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |