Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 8/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 9/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052880 | 0.91 | APOB (0.55) | APOBTP53MTTPSMOTRPV1 | |
| SCHEMBL6771574 | 0.87 | MTTP (0.54) | MCHR1HTR2CTP53MTTPTRPV1 | |
| SCHEMBL6769896 | 0.86 | TP53 (0.54) | MCHR1HTR2CHTTTP53TRPV1 | |
| SCHEMBL7688907 | 0.86 | MCHR1 (0.44) | APOBMCHR1HTR2CHTTTP53 | |
| SCHEMBL6770179 | 0.84 | APOB (0.54) | APOBMTTPSMOTRPV1 | |
| SCHEMBL6765677 | 0.84 | L3MBTL1 (0.52) | MCHR1HTR2CTP53TRPV1OPRL1 | |
| SCHEMBL6765643 | 0.83 | TRPV1 (0.46) | APOBMCHR1TP53MTTPTRPV1 | |
| SCHEMBL6766005 | 0.83 | MCHR1 (0.46) | MCHR1HTR2CHTTTP53MTTP | |
| SCHEMBL7550198 | 0.83 | BRAF (0.47) | APOBMCHR1HTR2CHTTMTTP | |
| SCHEMBL6769806 | 0.83 | TRPV1 (0.50) | MCHR1HTR2CTP53TRPV1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369075-B1 | 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B | PFIZER, INC. | 2002-04-09 | — | — | US | disclosed |