Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766198 | 0.89 | MTTP (0.47) | TP53TRPV1OPRL1MTTPMCHR1 | |
| SCHEMBL6769896 | 0.88 | TP53 (0.54) | TP53TRPV1HTTOPRL1MCHR1 | |
| SCHEMBL6765677 | 0.85 | L3MBTL1 (0.52) | TP53TRPV1OPRL1MCHR1HTR2C | |
| SCHEMBL6052880 | 0.85 | APOB (0.55) | TP53TRPV1MTTPLMNAALDH1A1 | |
| SCHEMBL6769806 | 0.84 | TRPV1 (0.50) | TP53TRPV1OPRL1MCHR1HTR2C | |
| SCHEMBL6769293 | 0.83 | P4HTM (0.51) | TP53HTTMTTPLMNAALDH1A1 | |
| SCHEMBL6771574 | 0.83 | MTTP (0.54) | TP53TRPV1OPRL1MTTPMCHR1 | |
| SCHEMBL6766005 | 0.83 | MCHR1 (0.46) | TP53TRPV1HTTOPRL1MTTP | |
| SCHEMBL6771468 | 0.82 | OPRL1 (0.50) | TP53TRPV1HTTOPRL1MCHR1 | |
| SCHEMBL7688907 | 0.82 | MCHR1 (0.44) | TP53TRPV1HTTOPRL1MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369075-B1 | 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B | PFIZER, INC. | 2002-04-09 | — | — | US | disclosed |