Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27571760 | 0.91 | CXCR2 (0.45) | HTTSMN1; SMN2MAPK1CNR1CXCR2 | |
| SCHEMBL7542421 | 0.89 | CXCR2 (0.39) | HTTLMNASMN1; SMN2CNR1CXCR2 | |
| SCHEMBL27571705 | 0.86 | CXCR2 (0.36) | PKMKMT2ACNR1CXCR2ATM | |
| SCHEMBL8002618 | 0.83 | CXCR2 (0.35) | CNR1CXCR2ATMCXCR1 | |
| SCHEMBL27608152 | 0.82 | CXCR2 (0.51) | CXCR2CXCR1 | |
| SCHEMBL7118983 | 0.81 | CXCR2 (0.43) | MEN1KMT2ASMN1; SMN2CNR1CXCR2 | |
| SCHEMBL27552241 | 0.78 | PLAU (0.39) | CXCR2CXCR1 | |
| SCHEMBL6550852 | 0.78 | CXCR2 (0.41) | CXCR2CXCR1 | |
| SCHEMBL27552112 | 0.77 | CASP3 (0.37) | MEN1KMT2ACXCR2CXCR1ALDH1A1 | |
| SCHEMBL7501094 | 0.77 | CXCR2 (0.44) | KMT2ALMNACNR1CXCR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500863-B1 | INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2002-12-31 | — | — | US | disclosed |