Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | MAP2 | P11137 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689211 | 0.88 | HTR6 (0.56) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7689209 | 0.78 | HTR6 (0.60) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL6968299 | 0.76 | NPC1 (0.51) | HTR6HTR1DHTR1BHTR2AJAK2 | |
| SCHEMBL2226181 | 0.74 | NPSR1 (0.60) | PFKFB3CMA1PFKFB4 | |
| Hydrochloric Acid SCHEMBL6712744 | 0.73 | NPSR1 (0.59) | PFKFB3CMA1PFKFB4 | |
| SCHEMBL6980951 | 0.72 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1548591 | 0.68 | NPSR1 (0.62) | HTR6PFKFB3CMA1PFKFB4 | |
| SCHEMBL1786156 | 0.67 | MAPT (0.54) | JAK2JAK1TYK2JAK3CSF1R | |
| SCHEMBL3224987 | 0.66 | KMT2A (0.52) | HTR6JAK2JAK1TYK2JAK3 | |
| SCHEMBL30760533 | 0.66 | KMT2A (0.52) | HTR6JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423717-B1 | NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-23 | — | — | US | disclosed |