Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689471 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1MAPTNTRK1NTRK3 | |
| SCHEMBL5873903 | 0.78 | MAPT (0.40) | KDM4EALDH1A1MAPTNTRK1NTRK3 | |
| SCHEMBL5873898 | 0.78 | MAPT (0.40) | KDM4EALDH1A1MAPTNTRK1NTRK3 | |
| SCHEMBL5873909 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPTNTRK1NTRK3NTRK2 | |
| SCHEMBL5873908 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPTNTRK1NTRK3NTRK2 | |
| SCHEMBL5873868 | 0.77 | RAB9A (0.42) | ALDH1A1MAPTNTRK1NTRK3NTRK2 | |
| SCHEMBL5873817 | 0.77 | RAB9A (0.42) | ALDH1A1MAPTNTRK1NTRK3NTRK2 | |
| SCHEMBL6879863 | 0.77 | GSK3B (0.46) | KDM4EALDH1A1MAPTNTRK1NTRK3 | |
| SCHEMBL6879859 | 0.77 | GSK3B (0.46) | KDM4EALDH1A1MAPTNTRK1NTRK3 | |
| SCHEMBL5873875 | 0.72 | MAPT (0.42) | KDM4EALDH1A1MAPTNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |