Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.55 |
| ▸ | FEN1 | P39748 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1167517 | 0.88 | ERCC5 (0.58) | ERCC5FEN1MAPTKMT2AMEN1 | |
| SCHEMBL30409701 | 0.83 | ERCC5 (0.63) | ERCC5FEN1MAPTKMT2AMEN1 | |
| SCHEMBL2057210 | 0.83 | ERCC5 (0.63) | ERCC5FEN1MAPTKMT2AMEN1 | |
| SCHEMBL6057368 | 0.81 | LMNA (0.64) | MAPTTP53ALDH1A1HPGDLMNA | |
| SCHEMBL9859579 | 0.81 | SMN1; SMN2 (0.50) | ERCC5FEN1MAPTKMT2AMEN1 | |
| SCHEMBL2375373 | 0.81 | LMNA (0.62) | ERCC5FEN1MAPTKMT2AMEN1 | |
| SCHEMBL26258777 | 0.81 | HPGD (0.49) | KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL11791699 | 0.79 | ERCC5 (0.76) | ERCC5FEN1MAPTTP53KMT2A | |
| SCHEMBL29962144 | 0.79 | ERCC5 (0.76) | ERCC5FEN1MAPTTP53KMT2A | |
| SCHEMBL18648612 | 0.78 | ERCC5 (0.57) | ERCC5FEN1MAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376521-B1 | ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2002-04-23 | — | — | US | disclosed |