SCHEMBL7689814

SCHEMBL7689814

O=S(=O)(Cl)c1cc(F)c2cccnc2c1O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
COMT P21964 11/20 0.57
L3MBTL1 Q9Y468 5/20 0.55
KDM4E B2RXH2 3/20 0.55
MEN1 O00255 2/20 0.55
ALDH1A1 P00352 2/20 0.55
LMNA P02545 2/20 0.55
MAPT P10636 2/20 0.55
KMT2A Q03164 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
POLB P06746 1/20 0.55
THRB P10828 1/20 0.55
PKM P14618 1/20 0.55
IDO1 P14902 1/20 0.55
RECQL P46063 1/20 0.55
TDO2 P48775 1/20 0.55
BLM P54132 1/20 0.55
CASP6 P55212 1/20 0.55
MPI P34949 1/20 0.47
MMP14 P50281 2/20 0.47
HSP90AA1 P07900 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4750143 0.86 COMT (0.54) COMTKDM4EMEN1ALDH1A1LMNA
SCHEMBL16049881 0.78 KDM4E (0.53) COMTL3MBTL1KDM4EALDH1A1MPI
SCHEMBL16207365 0.77 KDM4E (0.62) COMTL3MBTL1KDM4EMEN1ALDH1A1
SCHEMBL28471201 0.77 HSP90AA1 (0.62) COMTKDM4EMEN1ALDH1A1LMNA
SCHEMBL4457883 0.76 HSP90AA1 (0.72) COMTL3MBTL1KDM4EMEN1ALDH1A1
SCHEMBL22446563 0.76 L3MBTL1 (0.57) COMTL3MBTL1KDM4EMEN1ALDH1A1
SCHEMBL115570 0.76 KDM4E (0.72) COMTL3MBTL1KDM4EMEN1ALDH1A1
SCHEMBL7684587 0.76 KDM4E (0.64) COMTL3MBTL1KDM4EMEN1ALDH1A1
SCHEMBL17960045 0.75 COMT (0.47) COMTL3MBTL1KDM4EALDH1A1POLB
SCHEMBL2015831 0.75 L3MBTL1 (0.60) COMTL3MBTL1KDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed