Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689822 | 1.00 | GRM5 (0.47) | GRM5TGFBR1CHRNB2CHRNB1CHRNB4 | |
| SCHEMBL5848829 | 0.86 | LTA4H (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL5849027 | 0.86 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5849021 | 0.86 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5850633 | 0.86 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7701752 | 0.84 | CDK5 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4CYP11B1 | |
| SCHEMBL7701750 | 0.84 | CDK5 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4CYP11B1 | |
| SCHEMBL5848969 | 0.84 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL5848974 | 0.84 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL5849392 | 0.84 | CHRNB2 (0.42) | GRM5CHRNB2CHRNB1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002088114-A2 | HETEROARYL OFEFINIC AZACYCLIC AND HETEROARYL ACETYLENIC AZACYCLIC COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS | TARGACEPT, INC. (US) | 2002-11-07 | — | — | WO | claimed |