Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | MECP2 | P51608 | 1/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16456367 | 0.83 | POLB (0.73) | KMT2AMAPTSMN1; SMN2TP53HDAC3 | |
| SCHEMBL13390514 | 0.82 | SMN1; SMN2 (1.00) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL28966146 | 0.81 | HDAC6 (1.00) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL30285229 | 0.81 | HDAC6 (1.00) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL15441493 | 0.79 | HDAC3 (0.61) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL4122858 | 0.78 | NPC1 (0.76) | KMT2AMEN1MAPTSMN1; SMN2HDAC6 | |
| SCHEMBL9390447 | 0.77 | MEN1 (0.77) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL8401892 | 0.76 | TDP1 (0.73) | KMT2AMEN1MAPTSMN1; SMN2TP53 | |
| SCHEMBL1695444 | 0.76 | KDR (0.71) | KMT2AMEN1MAPTSMN1; SMN2HDAC6 | |
| SCHEMBL29851236 | 0.76 | KDR (0.71) | KMT2AMEN1MAPTSMN1; SMN2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | claimed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | claimed |
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | disclosed |